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2015 Vol. 68 No. 1

Original Basic Research And Clinical Articles2014-09-23
10.5173/ceju.2015.01.444
Timing of radical cystectomy in Central Europe - multicenter study on factors influencing the time from diagnosis to radical treatment of bladder cancer patients
Sławomir Poletajew, Bogdan Braticevici, Antonín Brisuda, Victor Cauni, Viacheslav Grygorenko, Martyn-Zenovii Lesnyak, Janusz Lisiński, Cristian Persu, Kacper Renk, Piotr Radziszewski
Time from unfavourable diagnosis to radical cystectomy (RC) affects oncological outcomes in patients with bladder cancer. Unsatisfactory survival of patients after RC in Central Europe can potentially result from this factor.
The aim of this study was to assess the time interval between transurethral resection of the bladder tumor (TURBT) and RC in Central Europe and to identify clinical factors of possible delays.

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Original Basic Research And Clinical Articles2014-11-23
10.5173/ceju.2015.01.466
Robot-assisted radical cystectomy and intracorporeal urinary diversion - safe and reproducible?
Allen Sim, Mevlana Derya Balbay, Tilman Todenhöfer, Stefan Aufderklamm, Omar Halalsheh, Johannes Mischinger, Johannes Böttge, Steffen Rausch, Simone Bier, Arnulf Stenzl, Georgios Gakis, Christian Schwentner, Abdullah Erdem Canda
Robot-assisted radical cystectomy (RARC) plus intracorporeal urinary diversion is feasible. Few centers worldwide demonstrated comparable functional and oncologic outcomes. We report a large series of RARC and intracorporeal diversion to assess its feasibility and reproducibility.

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Review Paper2014-11-16
10.5173/ceju.2015.01.448
Artificial urinary conduit construction using tissue engineering methods
Tomasz Kloskowski, Marta Pokrywczyńska, Tomasz Drewa
Incontinent urinary diversion using ileal conduit is most popular method used by urologists after bladder cystectomy resulted from muscle invasive bladder cancer. Use of gastrointestinal tissue is related with series of complications with necessity of surgical procedure extension which increase time of surgery. Regenerative medicine together with tissue engineering techniques gives hopes for artificial urinary conduit construction de novo without affecting the ileum. In literature there is still small number of works describing this topic that is why perfect solution for urinary conduit construction using tissue engineering does not exist

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Editorial Referring10.5173/ceju.2015.01.e93
Optimized management in patients with bladder cancer
Marek Babjuk

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Original Basic Research And Clinical Articles2014-10-20
10.5173/ceju.2015.01.424
The Comparison of the Effects of Two Different Bowel Preparation Methods on Sepsis Used at Transrectal Ultrasound Guided Prostate Biopsies
Mehmet Erol Yildirim, Hüseyin Badem, Mucahit Cavis, Omer Faruk Karatas, Ersin Cimentepe, Dogan Unal, Ilkay Bekir Incebay
Transrectal ultrasonography (TRUS) guided prostate needle biopsy is performed to diagnose and stage prostate cancer for many years. There are many different bowel preparation protocols to diminish the infectious complications but there is not a standardized consensus among urologists.We aimed to assess two different bowel preparation methods on the rate of infectious complications in patients underwent TRUS-guided prostate biopsy.

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Editorial Referring10.5173/ceju.2015.01.e92
Firing at a fly with a shotgun
Jan Hrbáček

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Original Basic Research And Clinical Articles2015-01-13
10.5173/ceju.2015.01.526
Bone Marrow Derived Cells Facilitate Urinary Bladder Regeneration by Attenuating Tissue Inflammatory Responses
Matthew I. Bury, Natalie J. Fuller, Linnea Wethekam, Arun K. Sharma
Inflammatory responses following tissue injury are essential for proper tissue regeneration. However, dysfunctional or repetitive inflammatory tissue assaults can lead to poor tissue regeneration and ultimate tissue failure via fibrosis. Previous attempts at urinary bladder tissue regeneration utilizing polymeric and biologic scaffolding materials tended to elicit these responses leading to poor tissue regeneration. Recent advances in bladder regeneration utilizing bone marrow derived mesenchymal stem cells (MSCs) and CD3+ hematopoietic stem/progenitor cells (HSPCs) with biocompatible citric acid based scaffolds have provided an environment that not only promotes the growth of architecturally germane and physiologically functional tissue, but also modulates aspects of the innate immune response.

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Original Basic Research And Clinical Articles2014-12-04
10.5173/ceju.2015.01.480
The histomorphological findings of kidneys after application of high dose and high-energy shock wave lithotripsy
Aslan Demir, Polat Türker, Suheyla Uyar Bozkurt, Yalcin Nazmi Ilker
In this animal study we searched the histomorphological findings in rabbit kidneys after high energy and high number of shock wave application and observed if these effects showed cumulative properties on repeated sessions.

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Original Basic Research And Clinical Articles2015-01-04
10.5173/ceju.2015.01.500
Flurbiprofen Alone and in Combination with Alfuzosin for the Management of Lower Urinary Tract Symptoms
Cevdet Serkan Gokkaya, Binhan Kagan Aktas, Cuneyt Ozden, Suleyman Bulut, Mehmet Karabakan, Akif Ersoy Erkmen, Ali Memis
We aimed to investigate the effectiveness and safety of flurbiprofen which is a non-steroidal anti-inflammatory drug with dual cyclooxygenase inhibition and α-blocker alfuzosin both alone and in combination with each other for lower urinary tract symptoms suggestive of benign prostatic obstruction (LUTS/BPO).

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Editorial Referring10.5173/ceju.2015.01.e94
The cardiovascular and gastrointestinal adverse effects of cyclooxygenase inhibitors seems to be a major concern that restricts their use in the treatment of urinary bladder dysfunction
Kajetan Juszczak, Tomasz Drewa

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Author's Reply10.5173/ceju.2015.01.r96
Reply to: Juszczak K, Drewa T. The cardiovascular and gastrointestinal adverse effects of cyclooxygenase inhibitors seems to be a major concern that restricts their use in the treatment of urinary bladder dysfunction. Cent European J Urol. 2015; 68: 57-59
Cevdet Serkan Gokkaya, Binhan Kagan Aktas

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Author's Reply10.5173/ceju.2015.01.r95
Reply to: Babjuk M. Optimized management in patients with bladder cancer. Cent European J Urol. 2015; 68: 15-16
Cristian Persu, Sławomir Poletajew

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Case Report2014-11-23
10.5173/ceju.2015.01.459
Intermittent Hyperammonemic Encephalopathy after Ureterosigmoidostomy: Spontaneous Onset in the Absence of Hepatic Failure.
Wolfgang Jäger, Anne-Odette Viertmann, Claudia Janßen, Frank Birklein, Joachim W. Thüroff, Raimund Stein
Intermittent hyperammonemic encephalopathy after ureterosigmoidostomy is a rare but if unrecognized potential lethal condition.. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

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Original Basic Research And Clinical Articles2015-01-10
10.5173/ceju.2015.01.498
Perioperative and survival outcomes of laparoscopic radical cystectomy for bladder cancer in patients over 70 years.
Pamela Portella Fontana, Sergio Alonso y Gregorio, Juan Gómez Rivas, Leslie Cuello Sánchez, Jesús Cisneros Ledo, Jesús Díez Sebastián, Jesús Javier de la Pena Barthel
Radical cystectomy in elderly patients is a controversial issue that increases importance overtime because average life span is growing. Our objective is to determine if there are significantly differences in perioperative outcomes in patients over 70 years with bladder cancer treated with laparoscopic radical cystectomy (LRC) compared with younger patients.

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Original Basic Research And Clinical Articles2014-11-23
10.5173/ceju.2015.01.465
CLINICAL, DEMOGRAPHICAL AND HISTOPATHOLOGICAL PROGNOSTIC FACTORS FOR UROTHELIAL CARCINOMA OF THE BLADDER
Ulku Kucuk, Emel Ebru Pala, Ebru Cakir, Ozlem Sezer, Umit Bayol, Rauf Taner Divrik, Ozgur Cakmak
Our aim is to evaluate the influence of the clinical and histopathological parameters including age, gender, tumor stage, grade, tumor differentiation, necrosis, lymphovascular/perineural (LVI/PNI) invasion, concomitant carcinoma in situ (CIS), on outcomes of patients with urothelial carcinoma of bladder.

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Original Basic Research And Clinical Articles2014-12-13
10.5173/ceju.2015.01.447
ROLE OF MORPHOMETRY AND PROLIFERATIVE PARAMETERS IN GRADING OF UROTHELIAL NEOPLASMS
Monika Sangwan, Sunita Singh, Santosh Kumar, Sonia Chabbra, Rajeev Sen, Praveen Rana, Shivani Malik, Sonia Singh, Ramesh Lamba
Mean nuclear area of 10 nuclei, Mitotic activity index and Ki67 are highly reproducible and can be routinely used as an adjunct to histopathological grading in classifying tumors. These biomarkers are non invasive, rapid, easy, more objective and accurate with high sensitivity and specificity and correlate well with grade.

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Original Basic Research And Clinical Articles2014-12-13
10.5173/ceju.2015.01.486
ASSOCIATION OF METALLOTHIONEIN EXPRESSION AND CLINICAL RESPONSE TO CISPLATIN BASED CHEMOTHERAPY IN TESTICULAR GERM CELL TUMORS
Emre Tüzel, Kutsal Yorukoglu, Esra Ozkara, Ziya Kirkali
The protective roles of metallothioneins (MT) against metal toxicity suggest that MT may have a functional role in cisplatin resistance The aim of this study was to investigate the expression of MT in specimens of germ cell tumors and compare it with clinical sensitivity to cisplatin based chemotherapy

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Original Basic Research And Clinical Articles2014-12-21
10.5173/ceju.2015.01.494
Quality of Life Related to Urinary Continence in Adult Spina Bifida Patients
Joceline S. Liu, Caroline Dong, Jessica T. Casey, Alyssa Greiman, Shubhra Mukherjee, Stephanie J. Kielb
To analyze the correlations of bladder management technique, ambulatory status and urologic reconstruction on quality of life (QOL) as affected by urinary symptoms in adult spina bifida (SB) patients.

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Review Paper2014-08-26
10.5173/ceju.2015.01.384
Mini-slings - an option in stress urinary incontinence treatment - case studies
Mariusz Blewniewski, Michał Markowski, Rafał Kliś, Waldemar Różański
Stress urinary incontinence (SUI) is a social disease caused by numerous contributing factors such as natural childbirth, overweight, hormonal deficiencies and changes in collagen fibers, to name a few. Currently, mini-slings, among all the surgical treatment methods, have gained significance. The aim of this study was to establish the effectiveness of this method.

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Review Paper2014-10-20
10.5173/ceju.2015.01.435
Mechanisms linking Obesity with male infertility
Atif Katib
Obesity in men is associated with infertility in numerous studies, and the epochal trend for a decline in semen parameters parallels the increasing prevalence of obesity worldwide. In addition to impaired semen quality, fertility among obese men may be affected by sexual dysfunction, Endocrinopathy, aromatization activity, psychological and thermal effects, sleep apnea, Leptin and minor toxins, and possibly the inflammatory and obstructive elements of epididymitis. Links are of variable degrees of certainties according to the levels of evidence supporting them

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Original Basic Research And Clinical Articles2015-01-10
10.5173/ceju.2015.01.508
Association between pre-biopsy white blood cell count and prostate biopsy-related sepsis
Suleyman Bulut, Binhan Kagan Aktas, Cevdet Serkan Gokkaya, Alp Ozgur Akdemir, Akif Ersoy Erkmen, Mehmet Karabakan, Ali Memis
To evaluate risk factors for the development of sepsis after prostate biopsy.

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Review Paper2014-11-11
10.5173/ceju.2015.01.474
Urinary Tract infections and Candida albicans
Payam Behzadi, Elham Behzadi, Reza Ranjbar
Urinary tract candidiasis is known as the most frequent nosocomial fungal infection worldwide. Candida albicans is the most common cause of nosocomial fungal urinary tract infections; however a rapid change in distribution of Candida species is undergoing. Simultaneously, the increase of urinary tract candidiasis has led to the appearance of antifungal resistant Candida species. In this review, we have a deep look into Candida albicans uropathogenesis and distribution of the first three most frequent Candida species contributing in urinary tract candidiasis in different countries around the world.

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Original Basic Research And Clinical Articles2015-01-18
10.5173/ceju.2015.01.496
A new corporoplasty based on stratified structure of tunica albuginea for the treatment of congenital penile curvature - long term results
Wojciech Perdzyński, Marek Adamek
The aim of the study was to report long-term results of treatment of the patients with congenital penile curvature (CPC) with a new corporoplasty based on stratified structure of tunica albuginea, in which cavernosal bodies are not opened.

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Dear Colleagues!

Please forgive me for this somewhat reflective mood, but it is caused by the up- coming end of the 2015-2018 term of the PUA Executive Board. As you probably know, the Editor-in-Chief of the Central European Journal of Urology is appointed by the PUA Executive Board, which is why this introductory article is somewhat of a summary.

So then, for this reason, I would like to share some information about the development of the journal. The journal is developing very well. When analyzing the names of the authors, we can see that we are recognizable not only in Europe but also around the world. Urologists from large academic centers publish their articles in our journal. We operate on an "open access" basis and therefore do not charge any fees. This is undoubtedly an asset. An expression of this is the growing number of our citations. The CiteScore coefficient for the Central European Journal of Urology is currently 1.11, while last year it was 0.70. The systematic increase in citations year by year sets the stage to move us from Emerging Cites Sources and promote us to the Science Citation Index Expanded, managed by Clarivate Analytics, formerly Thomson Reuters, which is associated with the granting of the socalled "Impact Factor". I first submitted our journal in 2015 and the assessment, at that time made by Thomson Reuters, was that we should remain in the "waiting room", and therefore we were included in Emerging Sources Citation Index. I submitted my second request for re-assessment at the end of 2017 and I am currently awaiting an answer. I hope to get a positive decision.

Building a urological journal in Europe is not a simple task. We already have journals of recognized position and reputation, such as European Urology, European Urology Focus, as well as World Journal of Urology, Urologia Internationalis, Scandinavian Journal of Urology and International Urology and Nephrology. There are also newly created journals such as European Urology Oncology which has very strong support from the European Association of Urology. We must show that we are needed in Central Europe! We do not have anything to prove!

The standing of a scientific journal depends firstly on the quality of the materials submitted, that is from the authors' workshops. However, this is only one side of the coin!

The team of people who verifies submitted scientific materials is also very crucial. This is probably the most important thing that I would like to convey. Usually, I do not officially direct words of thanks to my colleagues, because I think that they consciously chose the tasks they carry out in their lives. At this point, however, at the end of the 2015-2018 term of the PUA Executive Board, I would like to thank Dr. Bartosz Dybowski, my assistant Editor-in-Chief, for the enormous amount of work and time devoted to the extremely professional preparation of each issue. His ex- pert knowledge and availability could be the envy of many a manager. Without the hard work of Dr. Dybowski, this journal would not look like it does today, and the choice of his person for this position was certainly the right one.

I would also like to personally thank our section editors for their hard work and input. Przemysław Adamczyk, Ewa Bres-Niewada, Stefan Buntrock, Abdullah Erdem Canda, Michał Ciszek, Olga Dolejšová, Simona Di Francesco, Jan Hrbáček, Kajetan Juszczak, George Kasyan, Daimantas Milonas, Maciej Salagierski and Przemysław Waliszewski have always stood up to the task. Dear Colleagues, I know how much you have done for the journal, I appreciate it, and I will always remember your commitment.

Nothing could be done without the huge backing of internationally recognized professionals, without which the magazine would not be in the right form and would not grow. The Consulting Editors and the Editorial Board are these advisory bodies that I would like to thank for their knowledgeable comments and support in making difficult decisions.

Also, I would like to recognize the Reviewers, who often work "behind the scenes" but are nonetheless extremely helpful. Their complete independence allows them to give us their wise and unbiased opinions. Thank you for your support during the entire 2015-2018 term.

In conclusion, it is my sincere hope that the journal will continue to develop even better and even more vigorously in the coming years.


Tomasz Drewa
Editor-in-Chief

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Corrigendum
The Editorial Office would like to inform all interested parties that in Central European Journal of Urology an article entitled "Efficacy of holmium laser urethrotomy and intralesional injection of Santosh PGI tetra-inject (Triamcinolone, Mitomycin C, Hyaluronidase and N-acetyl cysteine) on the outcome of urethral strictures" [Kumar S, Kishore L, Sharma AP, Garg N, Singh SK. Cent European J Urol. 2015; 68: 462-465] was published which is very similar to the article entitled "Efficacy of Optical Internal Urethrotomy and Intralesional Injection of Vatsala-Santosh PGI Tri-Inject (Triamcinolone, Mitomycin C, and Hyaluronidase) in the Treatment of Anterior Urethral Stricture" published in Advances in Urology [Kumar S, Garg N, Singh SK, Mandal AK. Adv Urol. 2014; 2014: 192710. doi: 10.1155/2014/192710. Epub 2014 Oct 1].

The authors of these articles did not inform the CEJU Editorial Office about the prior publication of an article with a similar subject matter nor did they refer to it in their References section.

The Editorial Office regrets the existing situation.