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2011 Vol. 64 No. 3

Review Paper2011-05-27
The Integral System
Peter Petros
The Integral System is a total care management system based on the Integral Theory. It diagnoses and repairs damaged ligaments. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .


Review Paper2011-05-12
Treatment of Mixed Urinary Incontinence
Alex Gomelsky, Roger R. Dmochowski
Mixed urinary incontinence (MUI) is a prevalent condition and imposes a significant impact on a woman's quality of life.. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .


Editorial Referring10.5173/ceju.2011.03.art3
The calpain system as a potential target for pelvic muscle reinforcement.
Calpains and urinary incontinence
Robert M. Crayton, Piotr Radziszewski


Review Paper2011-07-01
The calpain system and urologic diseases. Part : Urinary incontinence.
Mariusz Blewniewski, Ewa Forma, Waldemar Różański, Magdalena Bryś
The fascial and muscular components within the pelvic floor create a support mechanism that facilitates storage and voiding of urine. Their constituents are mainly fibrillar collagens I and III responsible for maintaining tensile strength. Stretching and recoiling is enabled by the elastic fibers consisting of elastin on a scaffold of microfibrils, fibrillin-1 and-2. Calpains are intracellular Ca2+-dependent cysteine proteases found in almost all eukaryotes and some bacteria. Calpains display limited proteolytic activity at neutral pH, proteolysing substrates to transform and modulate their structures and activities, and are therefore called "modulator proteases"


Editorial Referring10.5173/ceju.2011.03.art5
New valve-mechanical model of urinary tract function: the theory of biological dual valves.
Do we need novel and innovative hypotheses in urology?
Tomasz Drewa, Georg Steinhauser


Original Basic Research And Clinical Articles2011-07-21
New Valve-Mechanical Model of Urinary Tract Function: The Theory of Biological Dual Valves
Arpad Dani, Peter Szendrö
Until now, peristalsis has been the only known method of urine transport. The main objective of this paper was to study urinary tract function - especially the upper urinary tract, the ureter - from a new mechanical point of view. The physical (physical dual valves) and biological basis (biological dual valves) of a new functional model is presented, based on previous observations and knowledge.


Editorial Referring10.5173/ceju.2011.03.art7
Is there a link between soft drinks and erectile dysfunction?
Dorota Olszewska-Słonina


Review Paper2011-05-09
Is there a link between soft drink and erectile dysfunction ?
Jan Adamowicz, Tomasz Drewa
This review focuses on the potential role of soft drinks, particularly the sugar component, in the pathogenesis of Erectile Dysfunction (ED). We analyzed hypothetical link between metabolic disorders, induced by sweetened soft drinks overconsumption, and ED. ). High caloric intake, high refined-carbohydrates and Fructose Corn Syrup (HFCS) content and less satiety are main factors responsible for metabolic disorders contributing to ED development. Regular diet mistakes, such as soft drink consumption, may lead a in human males to slow and asymptomatic progression of ED, finally resulting in full claimed manifestation of ED.


Original Basic Research And Clinical Articles2011-07-01
Salvage Open Radical Prostatectomy after Failed Radiation Therapy: a Single Center Experience
Michael A. Gorin, Murugesan Manoharan, Galaxy Shah, Ahmed Eldefrawy, Mark S. Soloway
Currently, there is no universally accepted approach for the management of radiation-recurrent prostate cancer. The aim of this report is to detail our experience performing salvage radical prostatectomy for patients who failed primary treatment of prostate cancer with radiation therapy.


Editorial Referring10.5173/ceju.2011.03.art10
Radical or simple nephrectomy in localized renal cell carcinoma: what is a choice?
Radical or simple nephrectomy for localized renal cell carcinoma - T he decision making is much more complex in 2011
Mark S. Soloway, David L.W. Pan


Editorial Referring10.5173/ceju.2011.03.art11
Radical or simple nephrectomy in localized renal cell carcinoma: what is a choice?
Radical or simple nephrectomy for localized renal cell carcinoma - The decision making is much more complex in 2011
Stanisław Wroński


Original Basic Research And Clinical Articles2011-06-21
RADICAL OR SIMPLE NEPHRECTOMY IN LOCALIZED RENAL CELL CARCINOMA: WHAT IS A CHOICE? Alexander Shulyak, Oleg Banyra. Danylo Halytsky Lviv National Medical University, Lviv, Ukraine. 2nd Lviv municipal polyclinic, Lviv, Ukraine.
Alexander Shulyak, Oleg Banyra
Renal cell carcinoma (RCC) accounts for approximately 3% of all adult malignancies. Surgery remains the only effective method of renal tumors treatment. In fact that in advanced RCC radical nephrectomy (RN) should remain a standard treatment. However, in localized RCC (LRCC) a real increase of survival rates realized by RN compare with simple nephrectomy (SN) or organ-sparing surgery is discussable. The aim of our study was to assess the impact of nephrectomy type on the prognosis of LRCC treatment.


Original Basic Research And Clinical Articles2011-07-01
Tranexamic Acid Decreases Blood Loss During Transurethral Resection Of The Prostate(TUR-P)
Şükrü Kumsar, Ayhan Dirim, Serdar Toksoz, Hasan S. Saglam, Öztug Adsan
Postoperative blood loss after prostate surgery is thought to be associated with an increase in urinary fibrinolytic activity. Tranexamic acid (TXA) is a potent inhibitor of plasminogen and urokinase activators and low molecular weight substance which is excreted unchanged in the urinary tract and can be administered both orally and intravenously. We investigated the effect of TXA on the amount of blood loss during transurethral resection of the prostate (TURP).


Original Basic Research And Clinical Articles2011-05-04
Operative shortening of the sling as a second-line treatment after the TVT failure.
Artur Gibas, Marcin Matuszewski, Jerzy Michajłowski, Kazimierz Krajka
Stress urinary incontinence (SUI) is defined as an involuntary loss of urine during physical exertion, sneezing, coughing, laughing or other activities that put pressure on the bladder. In some cases recurrent or persistent SUI after sling operations may be caused by too loose placement of the sling. In the current study, we describe our method of shortening of the sling as a second-line treatment of the TVT failure.


Editorial Referring10.5173/ceju.2011.03.art15
Detection of loss of heterozygosity in patients with urinary bladder carcinoma: neoplastic tissue vs. urine sedime nt cells.
Significance of CDKN2A gene A148T variant in patients with bladder cancer.
Toward a better understanding of bladder cancer - Genetic aspects are key
Tomasz Drewa


Original Basic Research And Clinical Articles2011-05-09
Detection of loss of heterozygosity in patients with urinary bladder carcinoma: neoplastic tissue vs. urine sediment cells
Magdalena Traczyk, Edyta Borkowska, Adam Jędrzejczyk, Michał Pietrusiński, Marek Rożniecki, Piotr Marks, Bogdan Kałużewski
Loss of heterozygosity (LOH) is frequently observed in urine bladder neoplasms. In the reported study, an attempt was undertaken to determine the loss of heterozygosity of TP53(17p13), RB1(13q1), CDKN2A/ARF(9p21) genes in DNA from neoplastic tissue, collected from patients with diagnosed urine bladder carcinoma, and to compare the results with those of LOH evaluation in DNA, isolated from urine sediment cells.


Original Basic Research And Clinical Articles2011-06-27
Significance of CDKN2A gene A48T variant in patients with bladder cancer
Edyta Borkowska, Adam Jędrzejczyk, Andrzej Kruk, Michał Pietrusiński, Magdalena Traczyk, Marek Rożniecki, Bogdan Kałużewski
A18T polymorphism of CDKN2A gene is observed in various neoplasms with the incidence rate of 3-35%, however, rather little is known either about the frequency of its occurrence or of its significance in urinary bladder carcinoma.


Original Basic Research And Clinical Articles2011-07-04
Effect of ALA-mediated photodynamic therapy in combination with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) on bladder cancer cells
Ewelina Szliszka, Aleksandra Kawczyk-Krupka, Zenon P. Czuba, Aleksander Sieron, Wojciech Krol
Photodynamic therapy (PDT), alternative treatment modality for superficial bladder tumors is based on the interaction of photosensitizer and light. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising candidate for anticancer therapeutic due to its ability to selectively induce apoptosis in cancer cells. However, not all tumor cells are sensitive to TRAIL. TRAIL-resistant cancer cells can be sensitized to TRAIL induced apoptosis by anticancer agents.. . . . . . . . . . .


Case Report2011-05-09
Retroperitoneoscopic ureterocutaneostomy as a method of urinary diversion in case of complicated urinary fistula after radiotherapy
Marcin Słojewski, Bogdan Torbé
The case of 71-year-old woman with massive vesico-vaginal and recto-vaginal fistula after radiotherapy treated with bilateral laparoscopic ureterocutaneostomy is presented. The retroperitoneoscopic access was applied. The technical aspects of the procedure are described. The interdisciplinary character of this not so uncommon problem is underlined. In our opinion this kind of procedure may be considered as a valuable alternative for usually used methods of urine derivation.


Case Report2011-05-09
Urethral diverticulum presenting as a scrotal mass in a paraplegic male: Report of a case and review of the literature
Ozlem Tokgoz, Husnu Tokgoz, Sema Yildiz
Male urethral diverticula are rare and can be congenital or acquired. We report a case of acquired urethral diverticulum presenting as a scrotal mass in a paraplegic male. On physical examination, the scrotal mass mimicked primary intrascrotal lesion. However, on retrograde urethrography, the correct diagnosis was made. The patient had a small incontinent spastic bladder with a history of prolonged catheterization. Eventually, the urethral diverticulum was excised including the affected segment of bulbous urethra


Case Report2011-04-19
Large tunica albuginea cyst simulating a large hydrocoele with a unique ultrasound feature.
Sani Aminu, Omar Jundi, Heshan Panditaratne
A 58 years old man presented with a large left scrotal swelling suspected

to be a large hydrocoele both clinically and on initial ultrasound. However

at operation a large tunica albuginea cyst was found arising from the mid

anterior wall of the left testis. It was dissected, excised and edges

under run. Further review of the ultrasound scan revealed a unique feature

of large tunica albuginea cyst simulating a hydrocoele.


Dear Colleagues!

Please forgive me for this somewhat reflective mood, but it is caused by the up- coming end of the 2015-2018 term of the PUA Executive Board. As you probably know, the Editor-in-Chief of the Central European Journal of Urology is appointed by the PUA Executive Board, which is why this introductory article is somewhat of a summary.

So then, for this reason, I would like to share some information about the development of the journal. The journal is developing very well. When analyzing the names of the authors, we can see that we are recognizable not only in Europe but also around the world. Urologists from large academic centers publish their articles in our journal. We operate on an "open access" basis and therefore do not charge any fees. This is undoubtedly an asset. An expression of this is the growing number of our citations. The CiteScore coefficient for the Central European Journal of Urology is currently 1.11, while last year it was 0.70. The systematic increase in citations year by year sets the stage to move us from Emerging Cites Sources and promote us to the Science Citation Index Expanded, managed by Clarivate Analytics, formerly Thomson Reuters, which is associated with the granting of the socalled "Impact Factor". I first submitted our journal in 2015 and the assessment, at that time made by Thomson Reuters, was that we should remain in the "waiting room", and therefore we were included in Emerging Sources Citation Index. I submitted my second request for re-assessment at the end of 2017 and I am currently awaiting an answer. I hope to get a positive decision.

Building a urological journal in Europe is not a simple task. We already have journals of recognized position and reputation, such as European Urology, European Urology Focus, as well as World Journal of Urology, Urologia Internationalis, Scandinavian Journal of Urology and International Urology and Nephrology. There are also newly created journals such as European Urology Oncology which has very strong support from the European Association of Urology. We must show that we are needed in Central Europe! We do not have anything to prove!

The standing of a scientific journal depends firstly on the quality of the materials submitted, that is from the authors' workshops. However, this is only one side of the coin!

The team of people who verifies submitted scientific materials is also very crucial. This is probably the most important thing that I would like to convey. Usually, I do not officially direct words of thanks to my colleagues, because I think that they consciously chose the tasks they carry out in their lives. At this point, however, at the end of the 2015-2018 term of the PUA Executive Board, I would like to thank Dr. Bartosz Dybowski, my assistant Editor-in-Chief, for the enormous amount of work and time devoted to the extremely professional preparation of each issue. His ex- pert knowledge and availability could be the envy of many a manager. Without the hard work of Dr. Dybowski, this journal would not look like it does today, and the choice of his person for this position was certainly the right one.

I would also like to personally thank our section editors for their hard work and input. Przemysław Adamczyk, Ewa Bres-Niewada, Stefan Buntrock, Abdullah Erdem Canda, Michał Ciszek, Olga Dolejšová, Simona Di Francesco, Jan Hrbáček, Kajetan Juszczak, George Kasyan, Daimantas Milonas, Maciej Salagierski and Przemysław Waliszewski have always stood up to the task. Dear Colleagues, I know how much you have done for the journal, I appreciate it, and I will always remember your commitment.

Nothing could be done without the huge backing of internationally recognized professionals, without which the magazine would not be in the right form and would not grow. The Consulting Editors and the Editorial Board are these advisory bodies that I would like to thank for their knowledgeable comments and support in making difficult decisions.

Also, I would like to recognize the Reviewers, who often work "behind the scenes" but are nonetheless extremely helpful. Their complete independence allows them to give us their wise and unbiased opinions. Thank you for your support during the entire 2015-2018 term.

In conclusion, it is my sincere hope that the journal will continue to develop even better and even more vigorously in the coming years.

Tomasz Drewa


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The Editorial Office would like to inform all interested parties that in Central European Journal of Urology an article entitled "Efficacy of holmium laser urethrotomy and intralesional injection of Santosh PGI tetra-inject (Triamcinolone, Mitomycin C, Hyaluronidase and N-acetyl cysteine) on the outcome of urethral strictures" [Kumar S, Kishore L, Sharma AP, Garg N, Singh SK. Cent European J Urol. 2015; 68: 462-465] was published which is very similar to the article entitled "Efficacy of Optical Internal Urethrotomy and Intralesional Injection of Vatsala-Santosh PGI Tri-Inject (Triamcinolone, Mitomycin C, and Hyaluronidase) in the Treatment of Anterior Urethral Stricture" published in Advances in Urology [Kumar S, Garg N, Singh SK, Mandal AK. Adv Urol. 2014; 2014: 192710. doi: 10.1155/2014/192710. Epub 2014 Oct 1].

The authors of these articles did not inform the CEJU Editorial Office about the prior publication of an article with a similar subject matter nor did they refer to it in their References section.

The Editorial Office regrets the existing situation.